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. 2018 Dec 28;11(1):28. doi: 10.3390/cancers11010028

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Classification of caspases. Caspases are divided into three subtypes: inflammatory caspases (1,4,5,11,12,13,14), initiator caspases in intrinsic and extrinsic apoptotic pathways with long N terminal (2,8,9,10), and effector caspases known for their short/absent N-terminal (3,6,7) [6,8]. (B) Classification of apoptotic proteins according to their function in apoptosis. Pro-apoptotic proteins are classified into Caspases and BCL-2 families. Caspases are further subdivided according to their role in apoptotic pathway. Bcl-2 proteins are classified as multidomain proteins (Bax and Bak) and BH3 only domain that either serve in intermediate pathway (Bid and inhibitors of apoptotic inhibitors such as SMAC/Diablo, HRTA/Omi, Noxa, Puma, Arts and Bim). Anti-apoptotic proteins are classified as BCL-2 multi-domain proteins (Bcl-xl, Bcl-b, Bcl-w, Mcl-1, Bf1 and DIVA/Boo) and BIR domain family (survivin, livin, bruce, c-IAP and x-IAP).