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Illustration of intrinsic, extrinsic, mitochondrial, and endoplasmic reticulum apoptotic pathways. The role of apoptotic proteins (black arrows), and their inhibition by anti-apoptotic proteins (Red) which are regulated by apoptotic inhibitors (Pink). An apoptotic cell is usually characterized by increased K+ efflux, surface blebbing, depletion of anti-oxidative markers such as GSH, chromatin condensation, and loss of cellular integrity.
