Table 1.

IC₅₀ values of various flavonoids in different types of cancer.

Compound	Cancer Type/Cell Line	Time Point (h)	IC50	Reference
Hesperetin	Myeloid	24	500 ± 100 µM	[222]
Naringenin	Lymphoid	48	164.9 ± 21.83 µM	[222]
EGCG	Breast T47D	72	14.17 µM	[49]
	Prostrate LNCaP	48	0.4 µM	[223]
	Prostrate PC3	48	38.95 µM	[224]
	Lung	24	70 µM	[225]
	Bladder		70–80 µM	[226]
	Acute T-lymphoblastic leukemia (CCRF-CEM)		16.04 ± 1.56 µM	[227]
Quercetin	Bladder	48	876.9 ± 13.1 µM	[222]
Kaempferol	Bone	24	148.4 µM	[222]
Fisetin	Erythroid	48	15 ± 2 µM	[222]
Myricetin	Colon	72	68.0 ± 20.4 µM	[222]
Galangin	Liver	24	100.4 ± 17.0 µM	[222]
Casticin	Lung A549	48	0.4 µMol/L	[228]
	Actute T-lymphoblastic leukemia (CCRF-CEM)	24 & 72	0.28 ± 0.02 µM	[227]
	Leukemia K562	48	5.95 µM	[229]
	Leukemia Kasumi-1	48	15.56 µM	[229]
	Leukemia HL-60	48	4.82 µM	[229]
Apigenin	ER- breast	24	60.4 ± 15.8 µM	[222]
Chrysin	ER+ breast	48	82.5 µM	[222]
Luteolin	Lung	72	35.9 ± 9.3 µM	[222]
Baicalein	Stomach	72	64.3 µM	[222]
Tangertin	Melanoma	48	0.3 µM	[222]
Acacetin	Oral squamous HSC-3	24	25 µg/mL	[162]
	MCF7	24	26.4 ± 0.7 µM	[167]
	Melanoma		0.79 mM	[230]
Flavopiridol	Bladder RT4/RTI12	24–72	150–350 nM	[231]
	Bladder T24/SUP	24–72	1000 nM	[231]
	GCT	72	60–70 nM	[232]
	SKOV, MCF-7, HeLa	72	280–350 nM	[232]
	Esophageal	72	100–150 mM	[233]
	HNSCC tumor xenografts	10 weeks	5 mg/kg/day	[234]
	Hematopoietic SUDHL4	12	120 mMol/L	[235]
	Prostrate PC3	12	203 mMol/L	[235]
Wogonin	Ovarian	72	19.9 ± 1.2 µM	[222]
Eupatorin	HeLa		11.72 ± 2.86 µM	[236]
	K562		4.29 ± 1.35 µM	[236]
	MCF7		16.61 ± 5.56 µM	[236]
	RPMI8226		4.77 ± 0.51 µM	[236]
	HL-60		14.09 ± 0.55 µM	[236]
	MOLT		4.74 ± 0.43 µM	[236]
	MDA-MB-468	96	0.5 µM	[182]
	MCF-7	96	50 µM	[182]
Cyanidin	HL-60	48	31.6 µM	[237]
Pelargonidin	HL-60	48	85.2 µM	[237]
	Osteosarcoma U2OS		15 µM	[200]
	HepG2	24	33 µM	[238]
Delphinidin	HepG2	24	77 µM	[238]
	HL-60	48	10.9 µM	[237]
Genistein	Hepatocellular Hepa1-6	24	20 µM	[239]
	Pancreatic Mia-PaCa2	24	20 µM	[240]
	Pancreatic PANC-1	24	25 µM	[240]
	Pancreatic H6C7	24	120 µM	[240]
	Colorectal HCT 116	24	690 µM	[217]
	Colorectal HCT 116	48	135 µM	[217]
	Colorectal HCT 116	72	61 µM	[217]
Daidzein	Colorectal HT-29	48	200 µM	[241]
	MIA PaCa-2	48	200 µM	[241]
	Ovarian SKOV3 [224]	24	20 µM	[242]
	BEL-7402	48	59.7 ± 8.1 µM	[243]