Table 3.

Temperatures used for HIPEC.

Temperature	Type of Hyperthermia	Cytotoxic Effect	Thermosensitization	Vascular Effect	Immune Reaction
39–41 °C	Mild	Minimal growth arrest	Synergism with cytotoxic drugs	Increased blood flow	Enhanced
31–43 °C	Moderate	Reversible growth arrest	Significant increased effect combined with cytotoxic drugs	Increased blood flow	Enhanced
>43 °C	Severe	Exponential growth arrest, significant cytotoxicity in normal cells	Significant increased effect combined with cytotoxic drugs	Reduced blood flow	Suppressed