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. 2019 Jan 5;17(1):28. doi: 10.3390/md17010028

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Tetrodotoxin (TTX) and analogs modified from European Food Safety Authority (EFSA) 2017 [45] and Yotsu-Yamasshita et al. (2007) [15,53,54]. (*) indicates TTX analogs that occur in marine organisms with known relative toxicity. (A) 4-cysTTX(*), (B) tetrodonic acid, (C) 4,9-anhydroTTX(*), (D) 1-hydroxy-5,11-dideoxyTTX, (E) TTX and 12 analogs, (F) 5-deoxyTTX(*) and three analogs, (G) trideoxyTTX and two analogs, (H) 4-epi-5,6,11-trideoxyTTX and another analog, and (I) 4,4a-anhydro-5,6,11-trideoxyTTX and 1-hydroy-4,4a-anhydro-8-epi-5,5,11-trideooxyTTX (see radicals of the analogs in the Table 1).