Table 1.

Tetrodotoxin (TTX) and analogs shown in Figure 1 and modified from European Food Safety Authority (EFSA) 2017 [45] and Yotsu-Yamasshita et al. (2007) [15,53].

E	R1	R2	R3	R4	R5
TTX (*)	H	OH	OH	CH2OH	OH
4-epiTTX (*)	OH	H	OH	CH2OH	OH
6-epiTTX (*)	H	OH	CH2OH	OH	OH
11-deoxyTTX (*)	H	OH	OH	CH3	OH
6,11-dideoxyTTX	H	OH	H	CH3	OH
8,11-dideoxyTTX	H	OH	OH	CH3	H
11-oxoTTX (*)	H	OH	OH	CH(OH)2	OH
11-norTTX-6,6-diol	H	OH	OH	OH	OH
11-norTTX-6(R)-ol (*)	H	OH	H	OH	OH
11-norTTX-6(S)-ol (*)	H	OH	OH	H	OH
Chiriquitoxin	H	OH	OH	CH(OH)CH(NH3+)COO−	OH
TTX-8-O-hemisuccinate	H	OH	OH	CH2OH	OOC(CH2)2COO−
TTX-11-carboxylic acid	H	OH	OH	COO−	OH
TTX (*)	H	OH	OH	CH2OH	OH
F	R1	R2	R3	R4	R5	R6
5-deoxyTTX(*)	OH	CH2OH	H	H	OH	H
5,11-dideoxyTTX (*)	OH	CH3	H	H	OH	H
5,6,11-trideoxyTTX (*)	H	CH3	H	H	OH	H
8-epi-5,6,11-trideoxyTTX	H	CH3	H	H	H	OH
G	R1	R2
4,9-anhydro-5,6,11-trideoxyTTX	H	OH
4.9-anhydro-8-epi-5,6,11-trideoxyTTX	OH	H
H	R1	R2	R3	R4	R5
1-hydroxy-8-epi-5,6,11-trideoxyTTX	OH	H	OH	OH	H
4-epi-5,6,11-trideoxyTTX	H	OH	H	H	OH
I	R1	R2	R3
4,4a-anhydro-5,6,11-trideoxyTTX	H	OH	H
1-hydroxy-4,4a-anhydro-8-epi-5,5,11-trideooxyTTX	OH	H	OH