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. 2019 Jan 10;10(1):37. doi: 10.3390/genes10010037

Figure 1.

Figure 1

Chromosomal abnormalities found by multicolor fluorescence in situ hybridization (M-FISH) in lymphocytes of HL survivors. (a) Chromosome 12 with two double strand breaks (DSBs) in different arms of the same chromosome. (b) Balanced translocation t(1;6)(p?;p?). (c) Balanced translocation t(3;15)(p?;q?). (d) Balanced translocation t(12;18)(q?;p?); translocations in (b–d) resulting from erroneous DNA repair of two DSBs occurring on two nonhomologous chromosomes. (e) Rearrangement dicentric + deletion + translocation, resulting from four DSBs, two on the same chromosome X, one on chromosome 20 and one on chromosome 19. (d) Complex rearrangement resulting from multiple DSBs on multiple chromosomes, found in a cell with chaotic karyotype (chromoplexy). Red arrows represent centromeres, numbers represent the chromosomes involved in the rearrangement [48].