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Metaphase of a lymphocyte from a survivor of HL after 13 years post MOPP treatment, with multiple structural NCCA [33]. Note that the possible daughter cells emerge with different alterations such as deletion or translocation, as a result of erroneous mitotic segregation of only one aberrant chromosome. Even when the daughter cells do not share the same structural aberration between them or with the progenitor cell, they may be clonal cells with multiple NCCA and without CCA.
