Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 15;11(1):99. doi: 10.3390/cancers11010099

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Schematic diagram of the molecular function of KRT19 as a regulator of cancer properties through differential modulation of the Wnt/β-catenin/Notch signaling pathway in colon and breast cancers. KRT19 directly interacts with only β-catenin to regulate Wnt/Notch signaling pathway and control cancer properties in colorectal cancer (a). KRT19 directly binds to the β-catenin/RAC1 complex to regulate NUMB transcriptional activity, which is an upstream inhibitor of the Notch signaling pathway and negatively regulates breast cancer properties (b).