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Cell type-specific functions of autophagy in liver fibrosis. Hepatic stellate cells (HSCs) transdifferentiate into collagen-producing myofibroblasts (MFB) in liver fibrosis. This process depends on macroautophagy, which provides energy for the HSC activation. On the contrary, autophagy maintains cellular homeostasis in hepatocytes, Kupffer cells (macrophages), and liver sinusoidal endothelial cells, thereby counteracting fibrogenesis in the liver.
