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Effect of ACE2 overexpression in the RVLM on cardiovascular activity of SHRs.
(A) Time courses of systolic blood pressure (SBP) (left) and HR (right) in SHRs after injection of Lenti-GFP or Lenti-ACE2 into the RVLM (arrows). Values are mean ± SEM, n = 5/group, *P < 0.05 vs day 0, #P < 0.05 vs Lenti-GFP. (B) NE in 24-h urine in SHRs injected with Lenti-GFP or Lenti-ACE2. Values are mean ± SEM, n = 5/group, *P < 0.05 vs Lenti-GFP.
