Fig. 1.

Effects of BPC157 in human and rat GI muscle strips. A Bath application of 40 µmol/L BPC157 suppressed the amplitude of contraction of a human longitudinal axial muscle strip, but did not alter the contractile effect of 5-HT and the inhibitory effect of NE. B BPC157 suppressed the contractile responses in rat stomach, jejunal, ileal, and colonic muscle strips. Application of BPC157 attenuated the amplitude of contraction, but pre-incubation with BPC157 did not alter the contractile response elicited by 5-HT or NE. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01.