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Barrett SP et al. Models for the production of circularRNA [13]. A. Intron-pairing-driven circularzation. Intron1 and intron3 are formed circular structure via base-pairing. Then introns are removed or retained to form circRNA or ElciRNA. B. Lariat-driven circularization. That splice donor in 3’ end of exon1 covalently splices to splices to splice acceptor in 5’ end of exon 4 forms a lariat via exon skipping. Then the introns are removed via splicesome. CircRNA finally is formed.
