Table 3.
Function and clinical application of disease related CirRNAs
| Tumor | CirRNA | Function | Role |
|---|---|---|---|
| Expression in granule cells [69] | CircRNA_103827 | Two circRNAs co-regulated their targets (ANKRD20A90, KCNQ10T1, XIST) through the network “circRNA-miRNA-mRNA” | Be involved in glycometabolism, mitosisand ovary steroid synthesis |
| CircRNA_104816 | |||
| Preeclampsia (PE) [76] | Hsa_circ_0029601 | Significantly upregulated, It is combined with plasma protein factor (endoglin) | The prediction accuracy of pre-eclampsia can be improved significantly |
| Hsa_cirRNA_100782 | These findings advocate that the ceRNA regulatory network constructed by miRNAs and circRNAs benefit PE development | ||
| Has_circRNA_102682 | Had already verified the highly expressed mir-30a-3p in the placental tissues of PE women | ||
| Has_circRNA_104820 | |||
| Recurrent spontaneous abortion (RSA) [80] | CircRNA_104948 | Hsa_circRNAs_104792/miRNA-133a/HLA-G | Be taken as RSA biomarkers |
| CircRNA_104547 | |||
| Hsa_circRNA_101319 | |||
| Ovarian carcinoma [90] | Cirs-7 | MIr-7 sponge | CircRNAs may use their circularization to competitively inhibit the linear splicing and sponge function of miRNAs, and modulate the expression of metastasis-evoking genes, all contributing to the metastasis of ovarian carcinoma |
| Cervical carcinoma [88,89] | CDR1as | miRNA sponge (miR-7) | Tumor suppressor was performed by inhibiting the tumorigenic effect of mir-7 |
| CircHIPK3 | miRNA sponge | Regulation of cell growth | |
| Hsa_circ_0018289 | miRNA sponge (miR-497) | Promote tumor cell proliferation, migration and invasion | |
| Breast cancer [93,95] | CDR1as | miRNA sponge (miR-7) | Tumor suppressor was performed by inhibiting the tumorigenic effect of mir-7 |
| Circ-ABCB10 | miRNA sponge (miR-1271) | Promote tumor cell proliferation | |
| Hsa_circ_0001982 | - | Potential tumor biomarkers | |
| Endometrial cancer [98] | Circ-ITCH | miRNA sponge (miRNA-17, miRNA-224) | Circ-ITCH can competitively bind to miRNA-17 and miRNA-224, a process leading to the differential expression of p21 and PTEN (the formers’ targets) |
| Circ-ZNF91 | miRNA sponge (miRNA-23B, miRNA122A2) | The expression level of circ-ZNF91 was found to be negatively correlated with that of miRNA-23B or miRNA122A2 in endometrial cancer tissues, suggesting that circRNAs may serve as miRNA sponge to inhibit the expression of miRNA-23B and miRNA-122A2 |
PE: Preeclampsia; RSA: Recurrent spontaneous abortion; PTEN: Phosphatase and tensin homolog deleted from chromosome 10; CiRS-7: Circular RNA Sponge for miR-7.