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. 2019 Jan 15;11(1):361–369.

Figure 5.

Figure 5

PAX6 was a direct a target gene of miR-365 in the glioblastoma cell. A. One putative binding sites of the miR-365 in the 3’UTR of PAX6 are shown. B. The expression of PAX6 in the glioblastoma cell lines (U373, U87, A172 and U251) and one normal astrocyte line (NHAs) was measured using qRT-PCR. C. The luciferase activity was decreased in the U87 cell co-transfected with miR-365 mimic and PAX6-3’UTR-WT luciferase reporter. D. Ecoptic expression of miR-365 suppressed the PAX6 mRNA expression. E. Overexpression of miR-365 inhibited the protein pression of PAX6.