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. 2019 Jan 31;19:20. doi: 10.1186/s12876-019-0941-0

Table 5.

Odds ratios for 28-day mortality per unit increase in D-dimer in subgroups of patients

No. of events Non-adjusted P for interaction Adjust I P for interaction Adjust II P for interaction
Cirrhosis
 yes 63 1.4 (1.1, 1.8) 0.004 0.948 1.4 (1.1, 1.9) 0.016 0.479 1.4 (1.0, 2.0) 0.088 0.866
 no 52 1.4 (1.1, 1.9) 0.018 1.2 (0.8, 1.8) 0.361 1.5 (0.9, 2.4) 0.138
EASL-ACLF
 yes 59 1.6 (1.2, 2.1) 0.002 0.452 1.4 (1.0, 2.0) 0.039 0.797 1.4 (0.9, 2.3) 0.128 0.886
 no 56 1.4 (1.0, 1.8) 0.040 1.3 (0.9, 1.9) 0.105 1.4 (0.9, 2.1) 0.168
Coagulation failure
 yes 43 1.4 (1.0, 1.9) 0.024 0.688 1.2 (0.8, 1.6) 0.328 0.259 1.3 (0.7, 2.4) 0.322 0.623
 no 72 1.5 (1.2, 2.0) 0.003 1.5 (1.1, 2.1) 0.009 1.6 (1.0, 2.8) 0.060
Hepatic encephalopathy
 yes 31 1.3 (1.0, 1.8) 0.087 0.496 1.1 (0.8, 1.6) 0.648 0.161 1.1 (0.7, 1.6) 0.797 0.202
 no 84 1.5 (1.2, 1.9) 0.001 1.5 (1.1, 2.0) 0.005 1.6 (1.1, 2.3) 0.015
leukocyte counts
 < 4 × 109/L or > 12 × 109/L 28 1.7 (1.1, 2.6) 0.010 0.263 1.7 (1.0, 2.9) 0.054 0.254 2.1 (0.9, 4.5) 0.075 0.156
 4 × 109/L - 12 × 109/L 87 1.3 (1.1, 1.6) 0.007 1.2 (0.9, 1.6) 0.149 1.2 (0.9, 1.8) 0.256

Non-adjusted model adjust for: None

Adjust I model adjust for: age; international normalized ratio; leukocyte counts; serum bilirubin and serum creatinine

Adjust II model adjust for: age, red blood cells, hematocrit, albumin, neutrophil percentage, serum total bilirubin, international normalized ratio, C-reactive protein, hepatic encephalopathy, and ascites