Table 1.
Demographic and clinical characteristics of Alzheimer’s disease (AD) patients according to the presence of delusion symptom
| AD-D | AD-noD | p | All | ||
|---|---|---|---|---|---|
| (n = 171) | (n = 86) | (N = 257) | |||
| Sexa | (M/F) | 55/116 | 27/59 | 0.999 | 82/175 |
| (Ratio) | 0.47 | 0.46 | 0.47 | ||
| Age | (Years) | 79.84 ± 6.80 | 80.97 ± 6.22 | 0.254 | 80.21 ± 6.62 |
| Body mass index | (Kg/m2) | 26.81 ± 5.89 | 25.15 ± 6.03 | 0.106 | 26.30 ± 5.95 |
| Educational level | (Years) | 4.25 ± 3.83 | 4.26 ± 3.49 | 0.798 | 4.26 ± 3.72 |
| Social support networkb | Living alone | 34 (19.88%) | 2 (2.33%) | 0.000 | 36 (14.01%) |
| Living with family | 112 (65.50%) | 82 (95.35%) | 194 (75.49%) | ||
| Institutionalized | 25 (14.62%) | 2 (2.33%) | 27 (10.51%) | ||
| Concomitant treatments | (No. of drugs) | 6.60 ± 3.07 | 5.08 ± 3.12 | 0.026 | 6.15 ± 3.14 |
| Clinical characteristics | |||||
| MNA | 18.81 ± 5.77 | 20.98 ± 5.64 | 0.011 | 19.48 ± 5.81 | |
| ADL | 3.27 ± 1.98 | 3.89 ± 1.86 | 0.025 | 3.47 ± 1.96 | |
| IADL | 2.05 ± 2.39 | 2.87 ± 2.81 | 0.037 | 2.31 ± 2.55 | |
| CIRS-CI | 2.74 ± 1.62 | 2.73 ± 1.74 | 0.870 | 2.74 ± 1.66 | |
| ESS | 14.50 ± 3.29 | 15.80 ± 3.29 | 0.008 | 14.89 ± 3.33 | |
| SPMSQ | 5.29 ± 1.93 | 4.75 ± 1.87 | 0.014 | 5.11 ± 1.93 | |
| Age at onsetc | (Years) | 78.03 ± 6.68 | 78.84 ± 6.16 | 0.143 | 78.02 ± 6.53 |
| Disease duration | (Years) | 2.23 ± 0.88 | 2.09 ± 0.94 | 0.226 | 2.18 ± 0 90 |
| MMSE | 16.81 ± 5.92 | 18.33 ± 5.64 | 0.017 | 17.32 ± 5.86 | |
| NPI | 35.57 ± 20.94 | 22.72 ± 17.04 | 0.000 | 31.14 ± 20.57 | |
| NPI-Distress | 15.71 ± 8.08 | 9.32 ± 5.96 | 0.000 | 13.58 ± 8.02 | |
| Delusion symptom duration | (Years) | 2.99 ± 0.79 | – | – | 1.39 ± 1.18 |
| Delusion symptom severity | 6.38 ± 3.25 | – | – | 4.27 ± 4.01 | |
Values of continuous variables are presented as mean ± standard deviation (SD)
aFisher’s Exact Test for Count Data; bPearson’s Chi-squared test; cWelch Two Sample t-test. All the other variables were compared by the Wilcoxon rank sum test with continuity correction
AD-D AD patients with delusions, AD-noD AD patients without delusions, MNA Mini Nutritional Assessment, ADL Activities of Daily Living, IADL Instrumental Activities of Daily Living, CIRS-CI Cumulative Illness Rating Scale Comorbidity Index, ESS Exton-Smith Scale, SPMSQ Short Portable Mental Status Questionnaire, MMSE Mini-Mental State Examination, NPI Neuropsychiatric Inventory