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. 2019 Feb 1;16:24. doi: 10.1186/s12974-019-1406-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effects of Apelin 13 on the activation of AMPK/GSK-3β/Nrf2 pathway. a Effects of Apelin 13 on the expression levels of Nrf2 in nuclear. Lamin B was used as the internal control protein in nuclear. b Effects of Apelin 13 on the expression levels of Nrf2, NQO-1, HO-1, and Keap1 in cytoplasm. β-actin was used as the internal control protein in cytoplasm. c Effects of Apelin 13 on the phosphorylation levels of AMPK and ACC. d Effects of Apelin 13 on the phosphorylation levels of Fyn and GSK-3β. ^##P < 0.01 vs. the sham group; *P < 0.05, **P < 0.01 vs. the model group