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. 2019 Jan 31;19:24. doi: 10.1186/s12935-019-0739-8

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — SOX2 interfered with CDX2 transcriptional activity in CDX2-overexpressing and bile acid-treated gastric cell lines. a, b SOX2 inhibited KLF4, HNF4α, and cadherin 17 in CDX2-overexpressing GES-1 and AGS cells. c, d SOX2 inhibited the expression of KLF4 in DCA-treated GES-1 and AGS cells. Dosage: 200 μM for 24 h. e CDX2 transcriptional response element (TRE) reporter plasmids were cotransfected with a SOX2-overexpressing plasmid and a CDX2-overexpressing plasmid or their negative controls (NCs) in HEK293T cells. *P < 0.05; **P < 0.01; NS not significant (P > 0.05)