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. 2019 Jan 31;19:24. doi: 10.1186/s12935-019-0739-8

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — miR-21 was increased in bile acid-stimulated gastric cells and IM. a The expression of miR-21 in 6 gastric cell lines. b, c The expression of miR-21 was increased upon stimulation with DCA in a dose-dependent manner in GES-1 and AZ-521 cells. Dose: 50, 100, 150 and 200 μM for 24 h. d The expression level of miR-21 in normal gastric tissues and gastric intestinal metaplasia tissues; scale bars: 200 μm (top) and 100 μm (bottom). e qRT-PCR of miR-21 levels in 8 pairs of matched human IM specimens. Each symbol represents mean value of an individual patient. f Western blotting results indicated that the inhibition of SOX2 in bile acid-treated AGS cells was partially rescued in miR-21 knockdown AGS cells. *P < 0.05; **P < 0.01; NS not significant (P > 0.05)