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. 2019 Jan 31;19:23. doi: 10.1186/s12935-018-0709-6

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Schema of miR-451 regulated YWHAZ pathway. miR-451 markedly inhibited expression of β-catenin via YWHAZ and subsequently inhibited downstream gene cyclin D1, c-Myc expression, which leads to paclitaxel resistance. Thus, downregulation of miR-451 is able to upregulate YWHAZ expression so that may reduce paclitaxel resistance in IBC [41]