Fig. 6.
Positron emission tomography (PET) to autopsy comparisons. a 18F-flortaucipir standardized uptake value ratio (SUVR) images shown alongside corresponding histological slides for a 68-year-old man with behavioral variant frontotemporal dementia due to argyrophilic grain disease (AGD), a 4-repeat tauopathy and Braak Alzheimer’s disease stage 3. The red arrow denotes areas of signal uptake. b Histological slides across the hippocampus at the level of the lateral geniculate body immunostained for phospho-tau protein (Ser202, CP-13, 1:500, gift of Peter Davies). (i) CA1 sector showing abundant grains and few neurofibrillary tangles. (ii) CA 1 sector showing abundant grains and few neurofibrillary tangles. (iii) Subiculum showing grains and pretangles. (iv) Inferior temporal gyrus showing grains and pretangles. L, left