Table 2.

¹⁸F-flortaucipir standardized uptake value ratio in various regions of interest (for CBS, left is contralateral to symptom onset)

		CMF	RMF	SF	OF	IN	PO	PT	PC	TL	TP	WM CMF
Left or CL
Controls n = 53	Mean ± sd	1.06 ± 0.1	1.06 ± 0.1	1.03 ± 0.1	1.16 ± 0.1	1.11 ± 0.12	1.06 ± 0.09	1.09 ± 0.1	1.01 ± 0.09	1.14 ± 0.09	1.12 ± 0.1	1.2 ± 0.16
	[min, max]	[0.81,1.3]	[0.84,1.26]	[0.79,1.25]	[0.79,1.33]	[0.78,1.37]	[0.82,1.3]	[0.86,1.3]	[0.78,1.2]	[0.88,1.28]	[0.8,1.29]	[0.82,1.6]
nfvPPA n = 11	Mean ± sd	1.15 ± 0.09	1.09 ± 0.05	1.09 ± 0.05	1.2 ± 0.05	1.13 ± 0.05	1.19 ± 0.07	1.18 ± 0.05	1.08 ± 0.04	1.15 ± 0.05	1.14 ± 0.09
	[min, max]	[1,1.37]	[1.02,1.19]	[1.-3.1.18]	[1.1,1.26]	[1.05,1.24]	[1.1,1.35]	[1.12,1.26]	[1.02,0.16]	[1.08,1.24]	[0.97,1.31]	n/a
	p value	0.01	0.22	0.0306	0.19	0.84	0.0001	0.0016	0.003	0.88	0.53
CBS n = 7	Mean ± sd	1.05 ± 0.09	1.02 ± 0.06	1.01 ± 0.07	1.18 ± 0.06	1.11 ± 0.08	1.1 ± 0.08	1.12 ± 0.06	1.06 ± 0.07	1.15 ± 0.04	1.08 ± 0.06	1.29 ± 0.14
	[min, max]	[0.95,1.19]	[0.93,1.08]	[0.91,1.11]	[1.09,1.16]	[1.04,1.28]	[1,1.26]	[1.05,1.2]	[0.96,1.13]	[1.07,1.2]	[0.99,1.16]	[1.41,1.56]
	p value	0.59	0.29	0.44	0.65	0.77	0.44	0.36	0.09	0.79	0.38	0.33
MAPT n = 6	Mean ± sd	1.11 ± 0.33	1.07 ± 0.12	1.02 ± 0.27	1.22 ± 0.1	1.21 ± 0.1	1.14 ± 0.19	1.12 ± 0.13	0.96 ± 0.2	1.21 ± 0.1	1.4 ± 0.35
	[min, max]	[0.64,1.56]	[0.9,1.21]	[0.59,1.35]	[1.1,1.4]	[1.1,1.32]	[0.88,1.37]	[0.98,1.29]	[0.58,1.12]	[1.11,1.33]	[1.13,2.01]	n/a
	p value	0.92	0.71	0.96	0.26	0.048	0.22	0.45	0.98	0.15	0.015
bvFTD n = 10	Mean ± sd	1.05 ± 0.15	1.03 ± 0.14	1.01 ± 0.14	1.14 ± 0.17	1.05 ± 0.15	1.05 ± 0.14	1.08 ± 0.16	0.97 ± 0.13	1.12 ± 0.12	1.13 ± 0.13
	[min, max]	[0.8,1.21]	[0.81,1.23]	[0.8,1.23]	[0.88,1.38]	[0.78,1.25]	[0.81,1.3]	[0.84,1.41]	[0.77,1.2]	[0.91,1.29]	[0.85,1.3]	n/a
	p value	0.98	0.48	0.71	0.71	0.25	0.64	0.32	0.35	0.84	0.62
C9ORF72 & PGRN n = 6	Mean ± sd	1.08 ± 0.16	1.08 ± 0.13	1.02 ± 0.16	1.25 ± 0.1	1.12 ± 0.06	1.14 ± 0.1	1.22 ± 0.15	1.01 ± 0.11	1.18 ± 0.09	1.2 ± 0.16
	[min, max]	[0.96,1.39]	[0.95,1.3]	[0.92,1.31]	[1.12,1.41]	[1.06,1.21]	[1.06,1.34]	[1.01,1.44]	[0.91,1.22]	[1.07,1.32]	[1.05,1.46]	n/a
	p value	0.65	0.98	0.28	0.06	0.96	0.08	0.039	0.65	0.24	0.27
svPPA n = 2	Mean ± sd	1 ± 0.11	1.05 ± 0.04	1 ± 0.01	1.2 ± 0.07	1.18 ± 0.07	1.09 ± 0.07	1.11 ± 0.04	0.98 ± 0.08	1.23 ± 0.03	1.43 ± 0.07
	[min, max]	[0.92,1.08]	[1.03,1.08]	[0.99,1.01]	[1.15,1.25]	[1.13,1.23]	[1.04,1.14]	[1.08,1.15]	[0.92,1.04]	[1.21,1.25]	[1.38,1.47]	n/a
	p value	0.39	0.92	0.53	0.56	0.39	0.65	0.72	0.62	0.09	0.017
Right or IL
Controls n = 53	Mean ± sd	1.05 ± 0.1	1.05 ± 0.1	1.04 ± 0.1	1.17 ± 0.1	1.12 ± 0.12	1.07 ± 0.09	1.1 ± 0.09	1.01 ± 0.09	1.14 ± 0.09	1.13 ± 0.1	1.2 ± 0.16
	[min, max]	[0.78,1.28]	[0.83,1.23]	[0.79,1.28]	[0.78,1.35]	[0.8,1.42]	[0.81,1.28]	[0.85,1.24]	[0.78,1.17]	[0.88,1.27]	[0.88,1.41]	[0.8,1.58]
nfvPPA n = 11	Mean ± sd	1.1 ± 0.06	1.1 ± 0.04	1.08 ± 0.04	1.2 ± 0.06	1.12 ± 0.05	1.15 ± 0.04	1.18 ± 0.07	1.08 ± 0.05	1.15 ± 0.05	1.11 ± 0.07
	[min, max]	[1.01,1.17]	[1.01,1.16]	[1.03,1.16]	[1.12,1.34]	[1.05,1.24]	[1.1,1.23]	[1.09,1.34]	[1,1.17]	[1.1,1.29]	[1,1.25]	n/a
	p value	0.06	0.13	0.0453	0.37	0.85	0.0018	0.0029	0.0112	0.96	0.22
CBS n = 7	Mean ± sd	1.04 ± 0.08	1.01 ± 0.06	0.98 ± 0.05	1.18 ± 0.06	1.13 ± 0.04	1.08 ± 0.05	1.1 ± 0.09	1.04 ± 0.05	1.16 ± 0.06	1.08 ± 0.04	1.24 ± 0.1
	[min, max]	[0.94,1.18]	[0.92,1.07]	[0.91,1.04]	[1.06,1.25]	[1.01,1.14]	[1.01,1.14]	[0.97,1.19]	[0.95,1.07]	[1.06,1.22]	[1.02,1.13]	[1.12,1.41]
	p value	0.67	0.16	0.049	0.81	0.95	0.88	0.76	0.26	0.48	0.08	0.54
MAPT n = 6	Mean ± sd	1.09 ± 0.35	1.08 ± 0.15	1.02 ± 0.25	1.21 ± 0.1	1.21 ± 0.12	1.14 ± 0.19	1.13 ± 0.15	0.95 ± 0.17	1.21 ± 0.08	1.36 ± 0.35
	[min, max]	[0.56,1.49]	[0.91,1.33]	[0.61,1.34]	[1.1,1.32]	[1.09,1.36]	[0.88,1.42]	[0.9,1.35]	[0.62,1.1]	[1.12,1.32]	[1.1,2.05]	n/a
	p value	0.76	0.82	0.92	0.48	0.15	0.39	0.53	0.73	0.1	0.035
bvFTD n = 10	Mean ± sd	1.02 ± 0.12	1.03 ± 0.14	0.98 ± 0.13	1.12 ± 0.13	1.05 ± 0.14	1.05 ± 0.15	1.09 ± 0.14	0.96 ± 0.12	1.11 ± 0.1	1.05 ± 0.07
	[min, max]	[0.79,1.18]	[0.81,1.2]	0.77,1.14	[0.9,1.31]	[0.79,1.24]	[0.77,1.31]	[0.84,1.31]	[0.76,1.14]	[0.92,1.22]	[0.96,1.15]	n/a
	p value	0.61	0.69	0.19	0.28	0.17	0.76	0.51	0.32	0.55	0.007
C9ORF72 & PGRN n = 6	Mean ± sd	1.06 ± 0.2	1.08 ± 0.14	1.02 ± 0.16	1.26 ± 0.08	1.15 ± 0.09	1.16 ± 0.1	1.23 ± 0.15	1.02 ± 0.11	1.19 ± 0.08	1.17 ± 0.09
	[min, max]	[0.92,1.44]	[0.98,1.31]	[0.91,1.32]	[1.17,1.38]	[1.03,1.24]	[1.08,1.35]	[1.08,1.45]	[0.94,1.24]	[1.08,1.27]	[1.08,1.29]	n/a
	p value	0.46	0.96	0.21	0.042	0.54	0.045	0.037	0.88	0.21	0.62
svPPA n = 2	Mean ± sd	1.03 ± 0.08	1.07 ± 0.01	1 ± 0.1	1.17 ± 0.1	1.13 ± 0.09	1.12 ± 0.08	1.12 ± 0.07	1 ± 0.1	1.16 ± 0.1	1.21 ± 0.05
	[min, max]	[0.97,1.09]	[1.07,1.08]	[0.99,1.01]	[1.1,1.24]	[1.07,1.19]	[1.06,1.17]	[1.07,1.18]	[0.93,1.07]	[1.09,1.22]	[1.18,1.24]	n/a
	p value	0.65	0.75	0.42	0.93	0.96	0.39	0.82	0.89	1	0.15

CL contralateral so symptom onset for CBS group, CMF caudal middle frontal, RMF rostral middle frontal, SF superior frontal, OFL orbitofrontal, IF inferior frontal, IN insula, PO pars opercularis, PT pars triagularis, PC precentral, TL temporal lobe, TP temporal pole, WMCMF white matter caudal middle frontal, IL ipsilateral to symptom onset for CBS group

ROIs with significantly elevated signal compared to controls (p < 0.05) are italicized