Table 2.
Cancer Type | Healthy Living Index Score | P for Trend | P for Heterogeneity | Continuous, per Unit Increase in Score | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
≤10a | 11–12 | 13 | 14–15 | ≥16 | |||||||||||||
No. of Cases | No. of Cases | HR | 95% CI | No. of Cases | HR | 95% CI | No. of Cases | HR | 95% CI | No. of Cases | HR | 95% CI | HR | 95% CI | |||
Overall | 431 | 276 | 0.70 | 0.60, 0.82 | 171 | 0.79 | 0.66, 0.95 | 262 | 0.65 | 0.55, 0.76 | 217 | 0.61 | 0.51, 0.72 | <0.01 | 0.94 | 0.93, 0.96 | |
Type 1 | 338 | 216 | 0.70 | 0.59, 0.83 | 122 | 0.72 | 0.68, 0.98 | 210 | 0.66 | 0.55, 0.79 | 168 | 0.60 | 0.49, 0.72 | <0.01 | 0.94 | 0.92, 0.96 | |
Type II | 64 | 44 | 0.75 | 0.51, 1.11 | 32 | 1.01 | 0.66, 1.56 | 41 | 0.70 | 0.47, 1.05 | 39 | 0.76 | 0.50, 1.16 | 0.17 | 0.97 | 0.97 | 0.93, 1.02 |
Grade | |||||||||||||||||
Well-differentiated | 84 | 47 | 0.60 | 0.42, 0.86 | 32 | 0.72 | 0.48, 1.10 | 51 | 0.62 | 0.43, 0.88 | 51 | 0.66 | 0.46, 0.96 | 0.04 | 0.94 | 0.90, 0.98 | |
Moderately differentiated | 160 | 103 | 0.72 | 0.56, 0.92 | 70 | 0.90 | 0.68, 1.20 | 109 | 0.76 | 0.59, 0.98 | 86 | 0.69 | 0.52, 0.90 | 0.02 | 0.97 | 0.94, 0.99 | |
Poorly differentiated | 100 | 52 | 0.56 | 0.40, 0.79 | 29 | 0.57 | 0.37, 0.86 | 52 | 0.55 | 0.39, 0.77 | 42 | 0.49 | 0.34, 0.72 | <0.01 | 0.75 | 0.92 | 0.89, 0.96 |
Stage | |||||||||||||||||
Localized | 338 | 216 | 0.70 | 0.59, 0.83 | 136 | 0.80 | 0.65, 0.98 | 210 | 0.66 | 0.55, 0.79 | 173 | 0.61 | 0.50, 0.74 | <0.01 | 0.94 | 0.93, 0.96 | |
Regional/distant metastatic | 78 | 50 | 0.71 | 0.49, 1.01 | 32 | 0.83 | 0.55, 1.27 | 50 | 0.71 | 0.49, 1.02 | 43 | 0.70 | 0.47, 1.03 | 0.08 | 0.46 | 0.97 | 0.93, 1.01 |
Abbreviations: CI, confidence interval; HR, hazard ratio.
a Reference category was score of ≤10; adjusted for age at entry, education, nonalcohol energy intake, ethnicity, age at menarche, parity, combined estrogen and progesterone therapy, unopposed estrogen therapy, oral contraceptive use, family history of endometrial cancer, and age at menopause.