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. 2018 Nov 8;188(2):261–273. doi: 10.1093/aje/kwy249

Table 2.

Associations Between Healthy Lifestyle Score and Risk of Endometrial Cancer Among Women From the Women’s Health Initiative Study, United States, 1993–2016

Cancer Type Healthy Living Index Score P for Trend P for Heterogeneity Continuous, per Unit Increase in Score
≤10a 11–12 13 14–15 ≥16
No. of Cases No. of Cases HR 95% CI No. of Cases HR 95% CI No. of Cases HR 95% CI No. of Cases HR 95% CI HR 95% CI
Overall 431 276 0.70 0.60, 0.82 171 0.79 0.66, 0.95 262 0.65 0.55, 0.76 217 0.61 0.51, 0.72 <0.01 0.94 0.93, 0.96
 Type 1 338 216 0.70 0.59, 0.83 122 0.72 0.68, 0.98 210 0.66 0.55, 0.79 168 0.60 0.49, 0.72 <0.01 0.94 0.92, 0.96
 Type II 64 44 0.75 0.51, 1.11 32 1.01 0.66, 1.56 41 0.70 0.47, 1.05 39 0.76 0.50, 1.16 0.17 0.97 0.97 0.93, 1.02
Grade
 Well-differentiated 84 47 0.60 0.42, 0.86 32 0.72 0.48, 1.10 51 0.62 0.43, 0.88 51 0.66 0.46, 0.96 0.04 0.94 0.90, 0.98
 Moderately differentiated 160 103 0.72 0.56, 0.92 70 0.90 0.68, 1.20 109 0.76 0.59, 0.98 86 0.69 0.52, 0.90 0.02 0.97 0.94, 0.99
 Poorly differentiated 100 52 0.56 0.40, 0.79 29 0.57 0.37, 0.86 52 0.55 0.39, 0.77 42 0.49 0.34, 0.72 <0.01 0.75 0.92 0.89, 0.96
Stage
 Localized 338 216 0.70 0.59, 0.83 136 0.80 0.65, 0.98 210 0.66 0.55, 0.79 173 0.61 0.50, 0.74 <0.01 0.94 0.93, 0.96
 Regional/distant metastatic 78 50 0.71 0.49, 1.01 32 0.83 0.55, 1.27 50 0.71 0.49, 1.02 43 0.70 0.47, 1.03 0.08 0.46 0.97 0.93, 1.01

Abbreviations: CI, confidence interval; HR, hazard ratio.

a Reference category was score of ≤10; adjusted for age at entry, education, nonalcohol energy intake, ethnicity, age at menarche, parity, combined estrogen and progesterone therapy, unopposed estrogen therapy, oral contraceptive use, family history of endometrial cancer, and age at menopause.