Table 2.
Multivariable Models of Birth Weight, Body Mass Index, and Early-Life Weight Change and Mammographic Density, Early Determinants of Mammographic Density Study, United States, 1959–2008
| Variable | % Density | Dense Area | Nondense Area | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Not Adjusted for Adult BMIa | Adjusted for Adult BMIa | Not Adjusted for Adult BMIa | Adjusted for Adult BMIa | Not Adjusted for Adult BMIa | Adjusted for Adult BMIa | |||||||
| β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | |
| Birth weight, kgb | 1.36 | −1.57, 4.30 | 0.96 | −1.46, 3.38 | 3.40 | 0.05, 6.74 | 3.36 | 0.06, 6.66 | 2.97 | −7.93, 13.87 | 5.25 | −2.32, 12.82 |
| Absolute size | ||||||||||||
| BMI at 1 yearc | −0.86 | −1.71, −0.01 | −0.48 | −1.18, 0.22 | −0.47 | −1.37, 0.44 | −0.41 | −1.28, 0.46 | 3.50 | −0.38, 7.39 | 0.81 | −2.32, 3.93 |
| BMI at 4 yearsd | −1.57 | −2.43, −0.70 | −0.85 | −1.62, −0.09 | −0.44 | −1.71, 0.83 | −0.45 | −1.73, 0.82 | 7.28 | 2.84, 11.71 | 3.05 | −0.10, 6.20 |
| BMI at 20–29 yearse | −1.67 | −2.01, −1.34 | −0.55 | −0.89, −0.20 | −0.73 | −1.25, −0.21 | −0.66 | −1.35, 0.03 | 8.80 | 6.51, 11.09 | 2.26 | −0.05, 4.57 |
| Relative change | ||||||||||||
| Percentile rank change in weight from 0 months to 4 months (per 10-unit increase)c | −0.67 | −1.20, −0.13 | −0.41 | −0.85, 0.02 | −0.76 | −1.34, −0.18 | −0.65 | −1.23, −0.07 | 1.94 | −0.09, 3.96 | 0.45 | −0.97, 1.87 |
| Percentile rank change in weight from 4 months to 12 months (per 10-unit increase)f | −0.54 | −1.33, 0.25 | −0.08 | −0.72, 0.55 | 0.31 | −0.67, 1.29 | 0.34 | −0.65, 1.33 | 3.23 | −0.17, 6.64 | 0.70 | −1.64, 3.03 |
| Percentile rank change in weight from 1 year to 4 years (per 10 unit increase)g | −1.52 | −2.27, −0.77 | −0.82 | −1.46, −0.18 | −1.10 | −2.00, −0.19 | −1.07 | −1.98, −0.16 | 5.77 | 2.88, 8.66 | 1.74 | −0.33, 3.81 |
Abbreviations: BMI, body mass index; CI, confidence interval.
a Weight (kg)/height (m)2.
b Original model adjusted for age at interview, maternal prepregnancy BMI, maternal weight gain, maternal age at registration, maternal education, prenatal smoking exposure, race/ethnicity, and adult BMI at interview.
c Adjusted for everything in original model with the addition of birth weight.
d Adjusted for everything in previous model with the addition of BMI at 1 year.
e Adjusted for everything in previous model with the addition of BMI at 4 years.
f Adjusted for everything in previous model with the addition of percentile rank change in weight from 0 months to 4 months.
g Adjusted for everything in previous model with the addition of percentile rank change in weight from 4 months to 12 months.