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. 2019 Jan 24;25:700–710. doi: 10.12659/MSM.911579

Figure 2.

Figure 2

The effects of zoledronic acid on apoptosis in human umbilical vein endothelial cells (HUVECs) and human oral keratinocytes (HOKs) was measured by an Annexin-V conjugated to fluorescein isothiocyanate (FITC) apoptosis assay. The results are presented as the average ± standard deviation (SD) of three independent experiments. There was a significant difference between the control group and the human umbilical vein endothelial cells (HUVECs) treated with 100 μmol/L of zoledronic acid, and a significant difference between the control group and the human oral keratinocytes (HOKs) treated with 50 and 100 μmol/L of zoledronic acid (P<0.05). However, even the highest concentration (100 μmol/L) of zoledronic acid resulted in less than 10% of cell apoptosis. * P<0.05 zoledronic acid-treated vs. control.