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. 2019 Jan 2;3(2):262–276. doi: 10.1002/hep4.1302

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© 2018 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Pemt^–/–mice develop NASH when fed the HFD. Pemt^+/+ and Pemt^–/– mice were fed the chow diet or the HFD for 10 weeks. (A) Hepatic TG mass. (B) Representative hematoxylin and eosin staining of livers of Pemt^+/+and Pemt^–/– mice fed either the chow diet or the HFD for 10 weeks (magnification ×20). (C) PC:PE molar ratio. (D) Mass of PC and PE. (E) Plasma ALT levels. Values are means ± SEM (n = 6 per group). (F) Bip and ER stress‐responsive CHOP and densitometry. Values are means ± SEM (n = 4 per group). (G) mRNA expression of genes involved in inflammation (Cd68), fibrosis (Col1a1), and oxidative stress (Nox2). Values are means ± SEM (n = 5 per group) and are expressed relative to Pemt^+/+ mice fed the chow diet; 2‐way ANOVA, followed by Fisher’s LSD post hoc test. Values that do not share a letter are significantly different (P < 0.05).