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. 2019 Jan 2;3(2):262–276. doi: 10.1002/hep4.1302

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© 2018 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Dysregulation of expression of hepatic genes involved in BA homeostasis in Pemt^–/– mice. Hepatic mRNA levels of genes involved in BA synthesis, biliary secretion and basolateral import of BAs, biliary secretion of phospholipids, regulators of BA synthesis, BA homeostasis, and the alternative pathway of BA secretion into bile and circulation were determined in Pemt^+/+ and Pemt^–/– mice fed (A) chow or (B) the HFD and normalized to cyclophilin mRNA levels. Values are expressed relative to Pemt^+/+ mice on the same diet. Values are means ± SEM (n = 5 per group). Student t test; *P < 0.05.