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The JAK2/STAT3 pathway is the key target of CTS.
Notes: (A) EC109 cells were treated with IL-6 (25 ng/mL) for different times and STAT3 phosphorylation was detected by Western blot analysis. (B) EC109 cells were pretreated with the indicated concentrations of CTS for 24 hours and stimulated with IL-6 for 30 minutes. (C) HEK-Blue IL-6 cells were used to detect the inhibition of CTS.
Abbreviations: CTS, cryptotanshinone; JAK2, janus kinase-2; p, phosphorylated.
