Table S2.
Known-groups results
| HPT-SD score | Patient-reported HPT severitya = very mild or mild | Patient-reported HPT severity = severea or very severe | P-valueb | ||
|---|---|---|---|---|---|
|
| |||||
| N | Mean (SD) | N | Mean (SD) | ||
|
| |||||
| Item 1. Muscle cramps | 10 | 1.0 (1.1) | 24 | 4.9 (2.2) | <0.0001 |
| Item 2. Tingling | 10 | 1.0 (0.5) | 24 | 1.6 (0.9) | 0.0698 |
| Item 3. Numbness | 10 | 0.4 (0.5) | 24 | 1.5 (1.1) | 0.0039 |
| Item 4. Muscle spasms or twitching | 10 | 0.7 (0.5) | 24 | 1.9 (1.1) | 0.0024 |
| Item 5. Feelings of heaviness in arms or legs | 10 | 0.6 (0.7) | 24 | 1.5 (1.1) | 0.0277 |
| Item 6. Physical fatigue | 10 | 1.7 (0.7) | 24 | 2.7 (1.0) | 0.0084 |
| Item 7. Slowed or confused thinking (brain fog) | 10 | 0.7 (0.8) | 24 | 2.0 (1.1) | 0.0018 |
| Item 8. Anxiety | 10 | 0.9 (0.9) | 24 | 2.0 (1.3) | 0.0223 |
| Item 9. Sadness or depression | 10 | 0.5 (0.7) | 24 | 1.6 (1.2) | 0.0153 |
| Item 10. Impact sleep | 10 | 0.6 (0.7) | 24 | 1.3 (0.7) | 0.0236 |
| Item 11. Impact exercise | 10 | 0.5 (0.7) | 24 | 1.7 (0.5) | <0.0001 |
| Item 12. Impact work | 10 | 0.3 (0.5) | 23 | 1.2 (0.7) | 0.0005 |
| Item 13. Impact relationships | 10 | 0.2 (0.4) | 24 | 1.0 (0.8) | 0.0073 |
| HPT-SD symptom subscale score | |||||
| (1: Muscle crampsc; 2: Tingling; 3: Numbness; 4: Muscle spasms or twitching; 5: Feelings of heaviness in arms; 6: Physical fatigue; 7: Slowed or confused thinking) | 10 | 0.8 (0.3) | 24 | 1.9 (0.8) | 0.0002 |
| HPT-SD impact subscale score | |||||
| (10: Sleep; 11: Exercise; 12: Work; 13: Relationships) | 10 | 0.4 (0.5) | 23 | 1.3 (0.5) | <0.0001 |
Notes:
a
Groups based on responses to PGIS.
b
ANOVA tests “very mild to mild” subgroup with “severe to very severe” subgroup.
c
To calculate the HPT-SD Symptom subscale, item 1 was rescaled from an 11-point response scale to a 5-point response scale ranging from 0 to 4.
Abbreviations: HPT, hypoparathyroidism; HPT-SD, Hypoparathyroidism Symptom Diary; PGIS, patients’ global impression of symptom severity.