Figure 3.

Lack of immunosuppression by CD71⁺ erythroid cells in inflammatory bowel disease [IBD] patients. [A] Representative dot plots showing proliferation of CD4⁺ T cells in peripheral blood mononuclear cells [PBMCs] of an ulcerative colitis [UC] patient. [B] Percentages of CD4⁺ and CD8⁺ T cells proliferation in PBMCs of UC patients in the presence or absence of CD71⁺ erythroid cells. [C] Representative dot plots showing proliferation of CD4⁺ T cells in PBMCs of a Crohn’s disease [CD] patient. [D] Percentages of CD4⁺ and CD8⁺ T cells proliferation in PBMCs of CD patients in the presence or absence of CD71⁺ erythroid cells. [E] TNF-α production by PBMCs of UC patients; or [F] CD patients. [G] TNF-α production by PBMCs of UC patients; or [H] CD patients following in vitro stimulation with anti-CD3 as measured by ELISA. [I] Correlation of CD71⁺ erythroid cells frequency in mothers in the third trimester [T3] with faecal calprotectin [FCP] levels in meconium.