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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: ACS Nano. 2018 Feb 22;12(3):2292–2310. doi: 10.1021/acsnano.7b07281

Table 3.

Incidence and Mean Severity of Lung Pathologya,b

dose(μg) day particle
saline Clois Na Clois 30B I-Clois Na I-Clois 30B CS
30 1 0/4 (0.0) 4/4 (1.75)c 3/4 (0.75) 2/4 (0.5) 0/4 (0.0) 0/3 (0.0)
30 7 0/4 (0.0) 4/4 (2.25)c 1/4 (0.25) 0/4 (0.0) 0/4 (0.0) 0/4 (0.0)
30 28 1/4 (0.75) 3/4 (0.75) 0/4 (0.0) 0/4 (0.0) 0/4 (0.0) 0/4 (0.0)
300 1 4/4 (2.0)c 4/4 (1.5)c 4/4 (3.0)c 4/4 (2.25)c 4/4 (1.0)
300 7 4/4 (4.0)c 4/4 (1.5)c 4/4 (1.0) 2/4 (0.5) 4/4 (1.0)c
300 28 4/4 (3.0)c 3/4 (0.75) 1/4 (0.25) 2/4 (0.5) 3/4 (1.0)
a

Incidence is stated as the number of positive animals out of n = 4 per group.

b

Average severity score in parentheses ranged from 0 to 4.

c

indicates significant increase in severity compared to saline controls using Fisher’s exact test (p < 0.05).