Table 1.
Overview of the various clinical materials and analytical techniques used in the present work.
| Clinical material | Analyses | Outcome | |||||
|---|---|---|---|---|---|---|---|
| Group I Serum, different diagnoses (n = 40) | RIE | Nephelometry (#1 Siemens) | Nephelometry (#2 IMMAGE) | ELISA (mAbs WL02 & DJ01) | ELISA (in- house, pAbs) | MBSI (mAbs WL02 & DJ01) | No correlation nephelometry vs RIE or ELISA mAbs WL02 & DJ01 suitable for MBSI |
| Group II Serum, different diagnoses without (n = 40) or with (n = 5) anti-C1 q antibodies | RIE | – | Nephelometry (#2 IMMAGE) | – | ELISA (in- house, pAbs) | MBSI (mAbs WL02 & DJ01) | Validation of MBSI (serum/plasma) |
| Group III CSF, different diagnoses (n = 31) | – | – | – | – | ELISA (in- house, pAbs) | MBSI (mAbs WL02 & DJ01) | Validation of MBSI (CSF) |
| Group IV EDTA-plasma, SLE (n = 379) with/without nephritis (BILAG classification) controls n = 322 | RIE (not controls) | – | – | – | – | MBSI (mAbs WL02 & DJ01) | MBSI similar to RIE in SLE |