Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 25;9:3109. doi: 10.3389/fimmu.2018.03109

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Kartikasari, Prakash, Cox, Wilson, Boer, Cauchi and Plebanski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Cancer immune evasion and the epigenetic modifications counteracting such mechanisms. To escape from immune-mediated killing, cancer cells exploit several evasion strategies. These are (1) downregulation of antigen presentation and costimulatory molecules, which could be counteracted by the inhibitors of epigenetic regulators including DNA methyltransferase (DNMT), histone deacetylase (HDAC), histone acetyltransferase (HAT), or histone demethylase (HDM), (2) downregulation of chemokines that signal T cells to infiltrate tumor mass, again that could be inhibited by inhibitors of DNMT, HDAC, or EZH2, and (3) upregulation of coinhibitory/checkpoint ligands, which could also be blocked by a BET bromodomain inhibitor.