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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Nat Neurosci. 2017 Jun 19;20(8):1114–1121. doi: 10.1038/nn.4582

Figure 6. Active dendrites in MECII neurons can promote the precision of the temporal code of grid cell firing.

Figure 6

(a,d) A detailed compartmental model of a MECII stellate cell was used to simulate grid cell firing in a hybrid CAN–oscillatory-interference model with passive (a) or active (d) dendrites (see Online Methods for details). Left: voltage-gated sodium conductance density plotted against dendritic distance from soma. Right: color-coded firing rate maps. (b,e) Example traces of simulated somatic membrane potential during a firing field crossing in the model with passive (b) and with active (e) dendrites. Raster plots at top show timings of excitatory velocity-controlled oscillators (VCOs, red) and inhibitory ramp inputs (blue). (c,f) While phase precession degraded in the model with (c) passive dendrites (n = 80 spikes), the model with (f) active dendrites (n = 153 spikes) produced clear phase precession of spikes with reference to the LFP. Red lines represent circular–linear regressions.