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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Angew Chem Int Ed Engl. 2018 Apr 27;57(25):7508–7512. doi: 10.1002/anie.201802143

Figure 4.

Figure 4.

CFAP700 can detect endogenous FA generated via tetrahydrofolate metabolism. FVB-luc+ mice were injected (i.p.) with tetrahydrofolate (30 mpk) or DMSO, then aq. sodium bisulfite (25 mpk) or water, then 100 μM CFAP700 (100 μL, 1% DMSO, 1% BSA in PBS). The mice were imaged every 2.5 minutes from 0–25 min. (a) Representative images of FVB-luc+ mice injected with CFAP700, THF, and/or bisulfite. (b) Total photon flux, integrated from 0–25 min post injection. Error bars are ±SEM (n = 4–5). Statistical analyses were performed with a two-tailed Student’s t test where *P ≤ 0.05.