Table 1.
Demographics and baseline characteristics across BDNF Val66Met genotype in male and female white and black participants in the Health ABC study.
| White participants | |||||
|---|---|---|---|---|---|
| Val/Val carriers | Met carriers | ||||
| Males | Females | Males | Females | p value of interaction^ | |
| N (%) | 564 (34.9%) | 510 (31.5%) | 287 (17.7%) | 257 (15.9%) | 0.93 |
| Age, mean (SD) | 73.9 (2.9) | 73.6 (2.8) | 73.7 (2.9) | 73.4 (2.7) | 0.89 |
| Education < high school, % | 224 (39.7%) | 275 (53.9%) | 118 (41.1%) | 135 (52.5%) | 0.60 |
| Weight kg, mean (SD) | 81.3 (12.9) | 67.0 (12.6) | 81.4 (11.5) | 65.0 (11.8) | 0.12 |
| Diabetes, % | 76 (13.5%) | 40 (7.8%) | 37 (12.9%) | 18 (7.0%) | 0.85 |
| CES-D, mean (SD) | 3.8 (4.5) | 5.5 (5.9) | 4.3 (4.9) | 5.3 (6.0) | 0.17 |
| Baseline 3MS, mean (SD) | 92.3 (5.9) | 93.5 (5.4) | 92.7 (5.4) | 93.9 (5.4) | 0.98 |
| Gait speed (m/s), mean (SD) | 1.3 (0.2) | 1.2 (0.2) | 1.3 (0.2) | 1.2 (0.2) | 0.61 |
| Average self-reported time spent walking (min/week), mean (SD) | 136.4 (288.6) | 84.7 (108.3) | 129.9 (163.9) | 96.2 (125.4) | 0.99 |
| Black participants | |||||
| N (%) | 388 (37.0) | 567 (54.0) | 45 (4.3) | 50 (4.8) | 0.20 |
| Age, mean (SD) | 73.5 (2.8) | 73.2 (2.9) | 73.5 (2.7) | 73.2 (3.0) | 0.86 |
| Education < high school, % | 272 (70.1%) | 405 (71.4%) | 35 (77.8%) | 38 (76.0%) | 0.88 |
| Weight kg, mean (SD) | 81.7 (15.1) | 76.0 (15.7) | 80.2 (12.8) | 74.5 (17.6) | 0.99 |
| Diabetes, % | 91 (23.5%) | 117 (20.6%) | 6 (13.3%) | 7 (14.0%) | 0.72 |
| CES-D, mean (SD) | 4.4 (4.9) | 4.9 (5.2) | 3.0 (3.8) | 5.0 (5.6) | 0.20 |
| Baseline 3MS, mean (SD) | 86.3 (8.3) | 88.1 (7.8) | 88.0 (6.7) | 88.5 (7.8) | 0.50 |
| Baseline Gait Speed (m/s), mean (SD) | 1.1 (0.2) | 1.0 (0.2) | 1.1 (0.2) | 1.1 (0.1) | 0.26 |
| Average self-reported time spent walking (min/week), mean (SD) | 103.0 (158.1) | 54.4 (91.5) | 105.2 (201.1) | 63.3 (95.9) | 0.85 |
^
p values testing sex by BDNF Val66Met genotype interaction from 2-way analysis of variance for continuous variables and logistic regression for categorical variables.