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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Eur J Med Chem. 2018 Nov 23;163:320–332. doi: 10.1016/j.ejmech.2018.11.056

Scheme 4.

Scheme 4.

Synthesis of ‘Right-Side Analogues’– Linker Precursors. Reagents and conditions: (a) Cs2CO3, DMSO, 90 °C, 12 h, 67%; (b) 10% Pd/C, EtOH, NH2NH2, reflux, 12 h, 90%; (c) Pyr, ClCOOPh, 3 h, 40%; (d) NH2NH2-H2O, reflux, 3h, 30%; (e) formamidine acetate, acetic acid, reflux, 3 h, 46%.