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Hh Inhibition of PSZ Analogues in ASZ cells.
| Cmpd | IC50 (μM)a, b |
|---|---|
| PSZ | 0.50 ± 0.1 |
| 1 | 0.19 ± 0.03 |
| 17 | 0.032 ± 0.01 |
| 18 | 0.15 ± 0.02 |
| 19 | 0.020 ± 0.01 |
| 21 | 0.012 ± 0.005 |
| 23 | 0.74 ± 0.15 |
| 24 | 0.33 ± 0.12 |
| 25 | >10 |
| 26 | 0.22 ± 0.08 |
| 27 | 0.19 ± 0.10 |
| 28 | 0.024 ± 0.009 |
| 29 | 0.19 ± 0.03 |
| 30 | >10 |
IC50 values represent the Mean ± SEM of at least two separate experiments performed in triplicate.
All analogues evaluated following 48 h incubation.
