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. 2019 Feb 1;14(2):e0211577. doi: 10.1371/journal.pone.0211577

Table 3. Univariate proportional hazard regression of patient survival for tested variables.

Variable Factora N Relative risk 95% confidence interval P Overall model significance
Gender F 16 1 P = 0.207
M 65 1.5 0.7 to 2.9 0.229  
Age continuous 81 1 0.9 to 1.1 0.063 P = 0.062
Age  <45 6 P = 0.127
45–64 51 2.8 0.9 to 9.2 0.081  
65+ 24 2.6 0.8 to 8.9 0.126  
T 1–2 34 1     P = 0.038
3–4 29 1.9 1.1 to 3.5 0.017  
Unknown 18 1.8 0.9 to 3.4 0.079  
N 0–1 30 1     P = 0.006
2–3 33 2.4 1.4 to 4.3 0.003  
Unknown 18 2.1 1.1 to 3.9 0.037  
Stage 7th I-II 17 1     P = 0.009
III-IV 50 2.6 1.3 to 5.2 0.006  
Unknown 14 2.6 1.1 to 6.1 0.031  
Stage 8th I-II 26 1     P = 0.001
III-IV 41 2.9 1.6 to 5.4 0.001  
Unknown 14 2.4 1.1 to 5.1 0.029  
Grade 1 19 1 P = 0.876
2 29 1.1 0.6 to 2.3 0.619  
3 31 1.1 0.6 to 2.2 0.711  
Unknown 2 2.4 0.5 to 10.7 0.246  
HPV overall no HPV 49 1 P = 0.893
inactive HPV 11 0.9 0.4 to 1.8 0.763  
active HPV 21 1.1 0.6 to 1.9 0.776  
HPV DNA  no HPV 49 1 P = 0.964
HPV DNA+ 32 1.0 0.6 to 1.7 0.965  
HPV RNA  no HPV 60 1 P = 0.714
HPV RNA+ 21 1.1 0.6 to 1.9 0.712  
p16 p16 negative 36 1 P = 0.569
p16 + 22 1.2 0.7 to 2.0 0.603  
Unknown 23 0.8 0.4 to 1.5 0.510  
Alcohol No alcohol 11 1 P = 0.075
Occasional use 18 2.3 0.8 to 6.4 0.103  
Heavy use 8 4.0 1.3 to 12.3 0.015  
Unknown 44 2.5 0.9 to 6.3 0.059  
Smoking No smoking 8 1 P = 0.279
Former 9 2.7 0.7 to 10.3 0.138  
Current 20 2.7 0.8 to 9.1 0.115  
Unknown 44 2.7 0.8 to 8.7 0.099  

aFactors reaching statistical significance are highlighted by bold font