Table 6.
Predictors of total diagnostic interval, patient interval, and health service interval
|
Total diagnostic interval (n=370) |
Patient interval (n=337) |
Health system interval (n=337) |
|||||
|---|---|---|---|---|---|---|---|
| HR (95 CI) | p value | HR (95 CI) | p value | HR (95 CI) | p value | ||
| Any symptom | ·· | ·· | ·· | ·· | ·· | ·· | |
| Indigestion | 0·71 (0·56–0·89) | 0·0033 | 0·79 (0·62–1) | 0·051 | 0·74 (0·58–0·95) | 0·018 | |
| Decreased appetite | 1·42 (1·11–1·82) | 0·0058 | 1·15 (0·88–1·49) | 0·31 | 1·56 (1·19–2·06) | 0·0015 | |
| Fatigue | 1 (0·78–1·27) | 0·97 | 0·88 (0·68–1·15) | 0·35 | 1·03 (0·8–1·33) | 0·83 | |
| Weight loss | 0·84 (0·66–1·06) | 0·15 | 0·69 (0·54–0·89) | 0·0047 | 0·9 (0·7–1·17) | 0·44 | |
| Feeling different | 0·93 (0·74–1·17) | 0·52 | 1·24 (0·96–1·6) | 0·096 | 0·75 (0·58–0·96) | 0·024 | |
| Change in bowel habits | 1·15 (0·91–1·45) | 0·24 | 0·99 (0·78–1·26) | 0·95 | 1·12 (0·87–1·44) | 0·37 | |
| Jaundice | 1·38 (1·07–1·78) | 0·013 | 1·29 (0·99–1·68) | 0·056 | 1·19 (0·91–1·55) | 0·20 | |
| Back pain | 0·77 (0·59–0·99) | 0·040 | 0·85 (0·65–1·12) | 0·25 | 0·76 (0·58–0·99) | 0·044 | |
| Sex (ref=female) | ·· | ·· | ·· | ·· | ·· | ·· | |
| Male | 1·23 (0·98–1·56) | 0·080 | 0·93 (0·73–1·18) | 0·55 | 1·41 (1·1–1·81) | 0·0072 | |
| Age at diagnosis (10 years) | 1·1 (0·98–1·22) | 0·10 | 1·08 (0·97–1·22) | 0·16 | 1 (0·9–1·12) | 0·95 | |
| IMD quintile (ref=least deprived) | ·· | 0·51 | ·· | 0·42 | ·· | 0·35 | |
| 2nd quintile | 0·94 (0·73–1·22) | ·· | 0·87 (0·66–1·16) | ·· | 0·84 (0·63–1·1) | ·· | |
| 3rd quintile | 1·17 (0·85–1·6) | ·· | 1·1 (0·79–1·53) | ·· | 1·08 (0·77–1·5) | ·· | |
| 4th quintile | 1·23 (0·84–1·82) | ·· | 1·26 (0·84–1·9) | ·· | 0·97 (0·64–1·45) | ·· | |
| Most deprived | 0·91 (0·52–1·6) | ·· | 1·16 (0·66–2·06) | ·· | 0·68 (0·39–1·19) | ·· | |
| Diabetes | 0·71 (0·52–0·97) | 0·029 | 1·06 (0·76–1·49) | 0·72 | 0·63 (0·45–0·89) | 0·0082 | |
| Gastrointestinal comorbidity | 1 (0·74–1·37) | 0·99 | 0·97 (0·69–1·35) | 0·84 | 1·22 (0·88–1·69) | 0·23 | |
| Self-reported anxiety or depression, or both | 0·67 (0·49–0·91) | 0·011 | 1·01 (0·73–1·41) | 0·95 | 0·63 (0·46–0·88) | 0·0064 | |
| Family history of cancer | 0·81 (0·64–1·03) | 0·083 | 0·93 (0·73–1·2) | 0·59 | 0·79 (0·61–1·02) | 0·067 | |
Proportional hazards Cox model adjusted for all variables in the table plus smoking status (never vs current vs ex-smoker) and living alone (yes vs no). The model includes patients with all diagnoses. HR=hazard ratio. IMD=Index of Multiple Deprivation.