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. 2018 Oct 12;41(1):29–37. doi: 10.1097/FTD.0000000000000570

FIGURE 2.

FIGURE 2.

Antimicrobial concentrations in selected patients over time. Antimicrobial concentrations in a patient treated with standard dosage of 13.5 g of PIP/TAZ for 24 hours (square) and a patient treated with individualized dosing according to the minimum inhibitory concentration (MIC) measured throughout the treatment period are shown. The target concentrations (100% f T >4MIC-percentage of time during a dosing interval that the free (f) drug concentration exceeded 4 times the MIC) for the second patient are highlighted as a black line (80 mg/L for unknown pathogen, and 20 mg/L for Escherichia coli with a MIC <4 mg/L).