Table 1.
Names and key features of the 257 serine protease-like proteins in D. melanogaster
| name | G-C-T-E | activation cleavage site |
specificity | domain | name | G-C-T-E | activation cleavage site |
specificity | domain | name | G-C-T-E | activation cleavage site |
specificity | domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cSP1/Grass | CuAD | LSQR*VSNG | T(DGG) | cP | SP126a | GWJH | QSGR*IKGG | C(GGD) | P | SPH169a | SYWI | DEDQ*MLNM | na | H |
| cSP3/Ser7 | CyAb | FSFR*LVGG | T(DGG) | cP | SP126b | GWJH | KDQR*IIGG | C(GGD) | P | SPH169b | SYWI | LDEK*LLYT | na | H |
| cSP4/SPE | CZAA | FADR*IFGG | T(DGG) | cP | SP129/ιTry | GIIH | ATGR*IIGG | T(DGG) | P | SP170 | SRTI | PKDI*IVNG | C(SGS) | P |
| cSP5 | CwAC | VTNR*IYGG | T(DGG) | cP | SP131 | GWJH | FQNR*VING | C(GGD) | P | SPH173 | SaqJ | QIRR*ETYG | na | H |
| cSP7/MP2 | CpAA | FSNK*VYNG | T(DGG) | cP | SP134/Phae1 | GchH | PEGR*VVGG | C(SGS) | P | SP175 | SsnL | RGPR*IIAG | C(GGG) | P |
| cSP8 | CuAB | GNPK*VSGG | C(HGG) | cP | SP135/Jon99Fii | GwGE | IQGR*ITNG | C(SVA) | P | SP176a | SNSL | ANSR*IVGG | T(DGG) | P |
| cSPH9 | CsAA | VRWQ*RSND | na | cP | SP137/Jon25Bi | GCGE | INGR*IVNG | E(SVS) | P | SP176b | SNmL | SKTR*IVGG | T(DGG) | P |
| cSP10 | CwAB | IRNR*IYDG | T(DGG) | cP | SP139/θTry | GIIH | REGR*IVGG | T(DGG) | P | SP178 | SqUM | STTK*VISF | C(GGG) | P |
| cSP11 | CwAD | AYNQ*ITKG | T(DGG) | cP | SP140 | GAhG | PEGR*IING | C(GGS) | P | SPH182 | SiQM | SSPK*FHGD | na | H |
| cSP12 | CpAB | VESR*LLGG | T(DGG) | cP | SP141 | GWJF | TKNR*IVGG | C(GGD) | P | SP183a | SNmL | RQGK*IFGG | T(DGG) | P |
| cSP14 | CZAC | PLYR*MAYG | T(DGG) | 4cP | SP143/Jon99Ciii | G4GE | IQGR*ITNG | C(SGA) | P | SP183b | SNSd | IQPR*IIGG | T(DGG) | P |
| cSP16 | CZAB | PAYR*IFGG | T(DGG) | cP | SP145/Jon65Ai | GPGE | IEGR*ITMG | C(GGK) | P | SPH184 | SjQM | FEML*ISGG | na | H |
| cSP18 | COAA | YFKK*IVGG | T(DGG) | 2cP | SPH146a | GWJH | PQGR*VIGG | na | H | SPH187 | SBLM | ADFK*SIGI | na | H |
| cSP19 | CXcC | STGR*IVGG | T(DGG) | cP | SPH146b | GWJH | FSSR*IVGG | na | H | SPH188 | SRTI | PDHI*ITNG | na | H |
| cSP24/Easter | CsAA | LSNR*IYGG | T(DGG) | cP | SP147/Phae2 | GchH | PEGR*VVGG | C(SGS) | P | SP189 | SuSM | FHPR*IYNG | C(TGT) | P |
| cSP25/MP1 | CpAA | FGDR*VVGG | T(DGG) | cP | SP150/Jon99Ci | G4GH | IEGR*ITNG | E(AVA) | P | SP190/Send2 | G4GH | PEER*IIGG | C(AGG) | P |
| cSP26/Snk | CUBB | SVPL*IVGG | T(DGG) | cP | SP151 | GRGE | AEGR*IVNG | E(SAS) | P | SP191 | SSSM | HETR*VIGG | T(DGG) | P |
| cSP28/Psh | CzBD | LVIH*IVGG | T(DGG) | cP | SP152 | GRGF | AEGR*IVNG | C(SGS) | P | SPH192a | SuSM | KFRR*VWGG | na | H |
| cSP31/Hayan | CzBA | LTVH*ILDG | T(DGG) | cP | SP153/Jon65Aii | GPGH | INGR*ITNG | C(GGK) | P | SPH192b | SuSM | PPVR*TLNK | na | H |
| cSP32 | CHCC | RSNR*IVGG | T(DGG) | cP | SPH161 | G6HH | PQGR*IAGG | na | H | SP193 | SxSM | WGDA*LHRG | C(GGR) | P |
| cSP33/Spirit | CyBD | FFVS*VVGG | T(DGG) | cP | SP165/Jon66Cii | GmGG | MQGR*ITNG | C(SGA) | P | SPH194a/Spx1 | SkTM | LSPR*IAGG | na | H |
| cSP34 | CncA | QFPR*LTGG | T(DGG) | cP | SP171/Jon66Ci | GmGG | IEGR*ITNG | E(GVA) | P | SPH194b/Spx2 | SkTM | LSPR*ITGG | na | H |
| cSPH35 | CcDA | VGFK*ITGA | T(DGG) | cP | SP174 | GWJF | LEHF*IVGG | E(GFD) | P | SPH195 | SMLI | GDQR*IING | na | H |
| cSP36 | CcaD | DQER*IVGG | T(DGG) | cP | SP177/Jon25Biii | GCGE | IEGR*ITNG | C(SVA) | P | SPH196a | SMIF | CNRT*TLGG | na | H |
| cSP38 | CrAB | SRRK*PTKG | T(DGG) | cP | SPH179 | G6HH | QSSR*LPAE | na | H | SPH196b | SMLI | AQSR*IIGG | na | H |
| cSP42 | ChBB | TTPF*IVGG | T(DGG) | cP | SP180/γTry | GIIG | LDGR*IVGG | T(DGG) | P | SPH197 | SDNK | RCGL*LTNG | na | H |
| cSP44 | CHCC | KSGR*IVGG | T(DGG) | TMcP | SP181/Jon99Fi | GwGE | IQGR*ITNG | C(SVA) | P | SPH199 | SnNL | LSPD*IVGP | na | H |
| cSP48 | CLBA | STPF*IVGG | T(DGG) | cP | SP185 | GWJH | LDNR*IVGG | C(GGD) | P | SPH200 | SnQM | RAKR*LSSP | na | H |
| cSP54 | CHbC | AQRR*IVGG | T(DGG) | cP | SP213/δTry | GIIG | LDGR*IVGG | C(GGD) | P | SPH201a | S1NK | LSND*IIFS | na | H |
| cSP56/Sb | CsCC | PETR*IVGG | T(DGG) | cP | SP215 | GIIG | LDGR*IVGG | C(GGD) | P | SPH201b | S1NJ | PHQD*VFKE | na | H |
| cSPH58 | CGDA | DNDKFPYS | na | 2cH | SPH235 | GAhH | IQPL*IIDG | na | H | SPH202/Intr | S2XM | IETL*LTDG | na | H |
| cSP59/Np | CHCC | PEPR*IVGG | T(DGG) | cP | SP15 | SfjL | PSSY*IVGG | T(DGG) | P | SPH206 | ShQL | YHQN*VVSI | na | H |
| cSP61 | CZAb | PVFR*DRGA | T(DGG) | cP | SP17 | SiMJ | IQKR*IVGG | T(DGG) | P | SPH207 | SEKL | VQFN*VTEG | na | H |
| cSPH64 | CdAB | VQGH*FYKG | na | cH | SP20 | SiML | TLYK*IVGG | T(DGG) | P | SPH214 | SmQM | RVKR*LSDG | na | H |
| cSPH66 | CndA | KNPV*YVDG | na | cH | SP21 | SbMJ | NVNR*IVGG | T(DGG) | P | SP216 | SJNL | PTNR*IVGG | T(DGG) | P |
| cSP67 | CHbB | LQKR*IIGG | T(DGG) | cP | SP22 | SiMd | TRHR*IVGG | T(DGG) | P | SP217 | SJNK | ISPK*IMHG | T(DGG) | P |
| cSPH69 | CEED | FSFR*EEDT | na | cH | SP23 | SuVN | EEIR*IVGG | T(DGG) | P | SP218 | SJNL | TAMR*VVNG | T(DGG) | P |
| cSPH79/Mas | COdC | RRAR*VVGG | na | 5cH | SP27 | SUPL | HDDF*NGRS | T(DGG) | P | SP219 | SJNK | VATR*IVRG | T(DGG) | P |
| cSPH93 | CdFa | NGLQ*MVEG | na | cH | SP29 | SpPJ | YVER*IFPN | T(DGG) | P | SP220 | SJNN | IAFK*IIGG | T(DGG) | P |
| cSPH94 | CbFD | GSPQ*VFGD | na | cH | SP37 | SKOJ | SQFK*ILGG | C(NGG) | P | SP221 | ShNL | FRIR*VIGG | C(YGG) | P |
| cSPH101 | CpdB | AAPG*QASF | na | cH | SP39 | SnMJ | DESR*IVGG | T(DGG) | P | SP223 | SKNJ | NEEH*QAHI | T(VGG) | P |
| cSP115 | CUBB | SQNL*LVGG | T(DGG) | cP | SP40 | SnML | NVNR*IVGG | T(DGG) | P | SP224 | SKOJ | GLYR*VING | C(SGG) | P |
| cSPH121 | CGDD | YQLD*GYNN | na | 2cH | SPH41 | SJNK | QCGL*MREE | na | H | SP225 | SKOK | YRAR*IDGG | T(DGG) | P |
| cSPH125 | CbeD | TVEE*VVDQ | na | cH | SP43 | S3PL | YTPL*IVGG | T(DGG) | P | SP43 | S3PL | YVPN*IFGG | T(DGG) | P |
| cSPH128 | CdED | HVNR*IGVG | na | cH | SP45 | S3PI | SRPL*IVDG | T(DGG) | P | SPH227 | SYWI | NSDN*IIAE | na | H |
| cSPH142/Scaf | CedA | TKPT*GVKD | na | 3cH | SP62 | SjOJ | FIPM*ITGG | T(DGG) | P | SP228 | SXjL | STYR*MVGG | T(DGG) | P |
| cSPH156 | CdFD | TERT*QPGG | na | cH | SP63 | SnnL | RNPK*IVGG | T(DGG) | P | SP230 | SBLI | PEER*IVGG | T(DGG) | P |
| cSPH166 | CcDB | LRPL*GYKQ | na | cH | SP68 | S3PI | YAPL*IIGG | T(DGG) | P | SP233 | S5YL | ILPK*IVGG | T(DGG) | P |
| cSP229 | CXAB | TTNR*VIGG | C(GGG) | cP | SP70 | ShkJ | QDGR*IVGG | T(DGG) | P | SP234 | SxpL | EDGK*IVNG | C(GGS) | P |
| cSPH231 | CEED | FSFR*EEDT | na | cH | SP73a | SsNK | HRTR*IIGG | C(NGG) | P | SPH236 | SiON | RIRR*VVGG | na | H |
| cSP232 | COAB | TSNR*VVGG | T(DGG) | cP | SP73b | SsNK | SVPR*VKNG | C(NGG) | P | SP237 | ShNL | YTYR*ITGG | E(YGL) | P |
| cSPH242 | CoDA | FTLS*GVSQ | na | cH | SP74 | SfNN | LRRR*ITGG | T(DGG) | P | SP238 | ShNL | FRMR*IFGG | C(FGG) | P |
| SP6 | GIIF | LDGR*IVGG | T(DGG) | P | SP82 | ShLK | GDGR*IVGG | T(DGG) | P | SP239 | SJNL | LSYK*IING | E(NGY) | P |
| SP46 | GzHF | LNGR*VVGG | E(GSD) | P | SP84 | SnTc | TDSY*AVGQ | T(DGG) | P | SP240 | SJNK | ISER*SVNA | E(QGK) | P |
| SP47/Ser6 | GzHH | LNGR*VVGG | E(GVD) | P | SP86 | S5YN | IEPK*IVGG | T(DGG) | P | SP243 | SKOJ | VREQ*ILGG | C(SGG) | P |
| SP50 | GzHF | IEPR*IVGG | C(GGD) | P | SP92/Ser12 | SBLL | SPER*IVGG | T(DGG) | P | SPH244 | SdQJ | TTIK*INHY | na | H |
| SP51 | GPGH | IDGR*ITNG | C(SVA) | P | SP95 | SxYL | QQSR*IING | T(DGG) | P | SP245 | Sund | VGGR*IVST | T(DGG) | P |
| SP52 | GyGH | IDNR*IVSG | E(SVS) | P | SPH97 | SOKJ | PNGL*VANV | na | H | SP246 | SfNI | IRFM*ITGG | T(DGG) | P |
| SP57/ηTry | GIIH | SDGR*IVGG | T(DGG) | P | SP104 | SQLL | PQER*IVGG | T(DGA) | P | SPH249 | S1NK | HMER*INGS | na | H |
| SP65 | GhgF | ISTH*IVGG | T(DGG) | P | SP105 | SPTL | AMDR*IFGG | C(SGG) | P | SPH250 | S1NK | FLEQ*NCGK | na | H |
| SP71 | GnGH | VEPY*ITNG | C(SGA) | P | SP108 | S5YN | DPGR*IING | T(DGG) | P | SPH252 | S2XM | SKEP*VVTL | na | H |
| SP76λTry | GIIH | LDGR*IVGG | T(DGG) | P | SPH111 | SDNL | LGPR*IVNG | na | H | SPH253 | S2XM | QIVR*IINK | na | H |
| SP78 | GPGE | PSGR*ITGG | C(SGG) | P | SP113 | SBLI | WEQR*IIGG | C(TGG) | P | SPH254 | S5YN | FQLK*MVAP | na | H-TM |
| SPH81 | G6HH | PQGR*ILGG | na | H | SP118 | ShkL | EESR*IIGG | C(SGG) | P | SPH255/Aqrs | S2XM | YNRE*ALEE | na | H |
| SP83 | GdIE | PFGR*IVNG | T(DGG) | P | SP123 | SPTN | GSLR*IMNG | C(LGG) | P | SP30 | MnnJ | NMLK*IIGG | T(DGG) | 2TSP-P |
| SP85/Jon74E | GnGH | IGGR*IAGG | C(SGS) | P | SP124a | SNSL | IQSR*IVGG | T(DGG) | P | SP49 | MJNK | LIPK*IVGG | T(DGG) | PH |
| SP87 | GpgF | SISR*VVNG | C(GSG) | P | SP124b | SNSL | RSPR*IVGG | T(DGG) | P | SP53/ModSP | MsoN | IKQF*SSGG | C(SGN) | Fig. 1 |
| SP88/εTry | GIIE | LDGR*IVGG | T(DGG) | P | SP127 | SPTL | VRTR*IAGG | C(GGG) | P | SP55 | MVVI | QTPF*IHNG | C(GGG) | GdP |
| SP90/Ser8 | GgIH | LGGR*IVGG | T(DGG) | P | SP130 | SDNL | TAYR*IING | C(NGN) | P | SP60 | MVVI | FSPL*QIGG | E(GGP) | GdP |
| SP91 | GpgH | QMGR*VVNG | C(GSG) | P | SP132 | StnJ | WTKK*FLAK | C(SGG) | P | SP72/Tequila | MmnN | REER*VVRG | T(DGG) | Fig. 1 |
| SP96 | GWJH | PETR*VIGG | C(GGD) | P | SP133 | STUJ | SQER*VVGG | C(GGG) | P | SP75/Corin | MeiL | PSRR*IIGG | T(DGG) | Fig. 1 |
| SP98/Jon65Aiii | GPGE | IEGR*ITNG | E(SVA) | P | SP136 | SvkL | PDPR*IVGG | T(DGG) | P | SP77 | MhNK | TRPK*ISGG | T(DGG) | PH |
| SP99 | G6HF | VEPRI*VGG | E(GVD) | P | SP138 | SBLI | IPER*IVGG | T(DGG) | P | SP80a | MFRc | ATTR*IANG | T(DGG) | CUBP |
| SP100/Jon44E | GGGH | IEGR*ITMG | C(SGA) | P | SP148a | SQLL | LPTR*IVNG | T(DGG) | P | SP80b | MFRK | FPNR*IANG | T(DGG) | CUBP |
| SP102/αTry | GIIE | LDGR*IVGG | T(DGG) | P | SP148b | SQLL | FPTR*IVNG | T(DGG) | P | SP89/Ndl | MknL | GDGR*IVGG | T(DGG) | Fig. 1 |
| SP103 | GAhE | ATGF*VING | C(SGS) | P | SP149 | STUL | TPHR*IVGG | C(GGG) | P | SP120 | MFRL | RIPR*IASP | T(DGG) | CUBP |
| SP106/Try29F | GcfF | LDGR*IVGG | T(DGG) | P | SP154 | STUL | SPTR*INGG | C(GGG) | P | SPH144 | MVVI | TTPL*IFQG | na | GdH |
| SP107 | GbfF | LDGR*IVGG | T(DGG) | P | SP155 | SsoJ | PDSR*IVNG | T(DGG) | P | SP186/Gd | MyVL | SLPS*ITRG | C(SGA) | GdP |
| SPH109/κTry | GIIH | PEGR*IIMG | na | H | SPH157 | SEKL | VQFN*VTEG | na | H | SPH198 | MyqL | SLPK*MSAP | na | Fig.1 |
| SP110/ζTry | GIIH | PDGR*IVGG | T(DGG) | P | SP158 | SzOL | AKLT*WWNY | C(HGG) | P | SP212 | MVVL | TTPF*IVRG | C(GGG) | 2Gd-P |
| SP112/Jon25Bii | GCGE | IEGR*ITNG | E(SVD) | P | SP159 | SjSL | IQPR*IVGG | T(DGG) | P | SP222 | MLNK | IALK*ITGG | T(DGG) | PH |
| SPH114/Sphe | G6HH | AQGR*IMGG | na | H | SP160 | SxQM | FQFL*VTGG | T(DGG) | P | SPH241 | MhNK | KTSE*NINF | na | HH |
| SP116/yip7 | GPGE | ITGR*ITNG | C(SGA) | P | SP163/Send1 | SBLI | PSER*IIGG | C(GGG) | P | SPH247 | MLNJ | CGAP*ISNQ | na | HH |
| SP117/Jon65Aiv | GPGE | IGGR*ITGG | C(SGA) | P | SPH164 | SBiM | SSNG*IYNG | na | H | SP248 | MhNJ | PVPK*IISG | T(DGG) | PH |
| Sp119/βTry | GIIE | LDGR*IVGG | T(DGG) | P | SP167 | SSSM | FQTR*VVGG | T(DGG) | P | SP251 | MiNL | ITYR*VANG | T(DGG) | PH |
| Sp122/jon99cii | G4GE | IQGR*ITNG | C(SGA) | P | SP168/Sems | SSSM | YQTR*VIGG | T(DGG) | P |
Names, gene symbols (if available), G-C-T-E IDs, putative activation sites (*), predicted enzyme specificity (T for trypsin, C for chymotrypsin, and E for elastase) and its key determinants (in parentheses), as well as domain structures are enlisted. The 1st letters in the G-C-T-E IDs are group names: C for CLIPs, G for gut, M for other multi-domain, and S for other single-domain SPs/SPHs. The 2nd letters show chromosomal locations: A–Z and 1–6 for gene clusters and a–z for other genes (Fig. 3). The 3rd letters indicate positions (A–Y and a–q) in the phylogenetic trees (Fig. 2). The 4th letters mark major and minor expression assemblies A–N and a–d (Fig. 4). In domain structure, P stands for SP catalytic domain, H for non-catalytic SP-like domain, “c” for clip domain(s), and “TM” for transmembrane region. “CUB” and “Gd” domains are also indicated. More complicated domain structures are presented in Fig. 1.