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Regional biosynthesis of ACTH and α-MSH from POMC in the pituitary. CPE, carboxypeptidase E; MSH, melanocyte-stimulating hormone; N-AT, N-acetyltransferase; PAM, peptidylglycine α-amidating monooxygenase; PCSK: proprotein convertase subtilisin/kexin. Adapted from Getting (2006) and Cawley et al. (2016).
