Table 1.
Top six IPA-identified canonical pathways of genes differentially expressed by pituitary tissue of steers grazing endophyte-infected tall fescue and supplemented with 3 mg Se/d in vitamin–mineral mixes as either sodium selenite (ISe), SEL-PLEX (OSe), or a 1:1 mix of ISe and OSe (MIX)
| Canonical pathway | Number1 | Gene symbol | Ratio2 | Log (P-value) |
|---|---|---|---|---|
| Ephrin receptor signalling | 12 | ROCK2,EPHB6,ITGA3,SDC2,RACK1,LIMK2,EFNB3,STAT3,RAP1A,EPHA2,GRINA,LIMK1 | 0.068 | 3.57 |
| Th1 and Th2 activation pathway | 11 | PSENEN,TGFB1,IL1RL1,LTA,IL6R,mir-155,VAV1,IL27RA,STAT3,IFNAR1,IL18R1 | 0.060 | 2.83 |
| Th1 pathway | 9 | PSENEN,LTA,IL6R,mir-155,VAV1,IL27RA,STAT3,IFNAR1,IL18R1 | 0.066 | 2.74 |
| Breast Cancer Regulation by Stathmin1 | 11 | ROCK2,TUBB4B,PPP2R3A,PPP1R14D,PRKCD,RACK1,ARHGEF1,LIMK2,ARHGEF3,PPP1CA,LIMK1 | 0.053 | 2.43 |
| Ephrin B Signalling | 6 | ROCK2,EPHB6,RACK1,VAV1,EFNB3,LIMK1 | 0.080 | 2.38 |
| Mitochondrial dysfunction | 10 | FURIN,SDHB,ATP5G1,PSENEN,COX7A2,LRRK2,CYB5A,GPX4,NDUFAB1,NDUFA2 | 0.053 | 2.29 |
1The number of genes (listed in the “Symbol” column) associated with the particular canonical pathway.
2The ratio is calculated as the number of genes in a given pathway that meet cutoff criteria (e.g., the ANOVA P-value for the differential expression among Se groups is <0.005) divided by the total number of genes that make up that pathway.