Table 2.
AR CALUX® Assay Results
| Substance | Agonism Assay |
Antagonism Assay |
Antagonism Assay IC50 |
|---|---|---|---|
| Positive or Negative (+/−) | (µM)a | ||
| Flutamide | NT | + | 0.876 |
| Hydroxyflutamide | NT | + | 0.0282 |
| Genistein | — | − | — |
| Resveratrol | — | + | 21.7 |
| Rutin hydrate | — | − | — |
| Quercetin hydrate | — | − | — |
| DIM | — | + | 1.27 |
| Bakuchiol | — | + | 2.85b |
| AG | — | − | — |
All values presented to 3 significant figures.
NT, not tested.
a
Best-fit IC50 from at least 3-independent experiments at a non-saturating concentration of DHT.
b
PC50 value presented as a reliable IC50 value could not be obtained from the dose-response.