Predicted effect of phytase dose and digestible lysine requirement on body weight gain (grams) of broilers from hatch to 42 d posthatch (Exp. 1). The model was determined as:! = −2,080 + 93.71!– 0.4768!+0.0599!– 1.3982e-5!R2 = 0.59. P < 0.0001. Diets were formulated to contain digestible lysine at ● 80%, ■ 88%, ▲ 96%, or × 104% of the requirement according to Cobb 400 breed guidelines (VenCobb 400 Broiler Management Guide, Cobb-Vantress Inc., Siloam Spring, AR); this corresponds to 1.02, 1.13, 1.23 and 1.33% dgLys, respectively, in the starter diets and 0.84, 0.92, 1.01 and 1.09% dgLys, respectively, in the grower diets. The digestible lysine concentration to maximize body weight gain was predicted at 98.2% of the requirement (1.23% dgLys in the starter diet and 1.03% dgLys in the grower diet), regardless of the dose of phytase supplied in the diet. The dose of phytase to maximize body weight gain was predicted at 2,146 FTU/kg of diet, regardless of the digestible lysine concentration of the diet.