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HGF stimulates PTGS2 expression through an MEK-dependent signaling pathway. Equine iTr cells were cultured for 36 h with 10 ng/mL of HGF in the presence or absence of 1 nM MK2206 (A) or 1 nM PD0325901 (B). Total RNA was isolated, reverse transcribed, and analyzed by real-time PCR for PTGES2 mRNA abundance. Fold change calculated relative to CON cells treated with vehicle only. Mean and SEM of three replicate experiments shown. *Significance at P < 0.05.
