Table 1.
Linear contrast coefficients used to estimate additive, dominance, and epistasis effects for µ-calpain (CAPN1) haplotype and F94L SNP
| Genotype mean1 | F94L2 | CAPN1 2 | F94L × CAPN13 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| F94L | CAPN1 | A | D | A | D | AA | AD | DA | DD |
| FF | NN-NN | −1 | −1 | −1 | −1 | 1 | 1 | 1 | 1 |
| FF | CC-NN | −1 | −1 | 0 | 2 | 0 | −2 | 0 | −2 |
| FF | CC-CC | −1 | −1 | 1 | −1 | −1 | 1 | −1 | 1 |
| FL | NN-NN | 0 | 2 | −1 | −1 | 0 | 0 | −2 | −2 |
| FL | CC-NN | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 4 |
| FL | CC-CC | 0 | 2 | 1 | −1 | 0 | 0 | 2 | −2 |
| LL | NN-NN | 1 | −1 | −1 | −1 | −1 | −1 | 1 | 1 |
| LL | CC-NN | 1 | −1 | 0 | 2 | 0 | 2 | 0 | −2 |
| LL | CC-CC | 1 | −1 | 1 | −1 | 1 | −1 | −1 | 1 |
| Divisor4 | 6 | 6 | 6 | 6 | 1 | 2 | 2 | 4 | |
1Estimated genotype means are identified by the 9 combinations of 3 MSTN F94L genotypes and 3 µ-calpain (CAPN1) diplotypes. F94L genotypes are designated by FF (homozygous F94LaF), FL (heterozygotes), and LL (homozygous F94LaL). CAPN1 diplotypes are designated NN-NN (homozygous CAPN1hNN), CC-NN (heterozygotes) and CC-CC (homozygous CAPN1hCC).
2Linear contrast coefficients multiplied by genotype means to estimate F94LaL and CAPNhCC haplotype additive (A) and dominance (D) effects.
3Linear contrast coefficients for 2-factor epistatic effects identified with 2 letters. The first letter is the F94LaL effect and the second letter is the CAPN1hCC haplotype effect, e.g., AD is additive F94L × CAPN1 dominance epistatic effect.
4Actual coefficients used were the whole numbers in table divided by this number.