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. 2018 Oct 4;60(2):312–317. doi: 10.1194/jlr.R089763

Fig. 1.

Fig. 1.

Nuclear PI-PLC β1 is essential in the synthesis of nuclear DAG. Possibly, this nuclear DAG is hydrolyzed by DAGLα to produce 2-AG. Released from the postsynaptic neuron, 2-AG can in turn activate cannabinoid receptor type 1 (CB1-R) on the presynaptic sites, repressing other NT release.